Which NFL odds should you target in a week with six teams on bye? Houston's opponent this week, the Arizona Cardinals, have only been road favorites once this season, but covered in that spot against Jacksonville.Īrizona has won four of its five road games this season by at least two touchdowns, but are massive 17.5 favorites in the latest NFL Vegas odds from Caesars Sportsbook. The Week 7 NFL schedule features six matchups with NFL spreads of 10 points or more, and the Texans are two-touchdown home underdogs this week. The only game last week to feature a double-digit spread was Houston at Indianapolis, where the Colts handily covered the 11.5-point margin in a 31-3 win.